What is the function of RAD50 protein?
| Molecular function | Hydrolase |
|---|---|
| Biological process | Cell cycle, DNA damage, DNA repair, Host-virus interaction, Meiosis |
| Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
What proteins are involved in DNA repair?
One detects the mismatch, and the other recruits an endonuclease that cleaves the newly synthesized DNA strand close to the region of damage. In E. coli , the proteins involved are the Mut class proteins: MutS, MutL, and MutH. In most Eukaryotes, the analog for MutS is MSH and the analog for MutL is MLH.
How many proteins are involved in DNA repair?
About 30 proteins are involved in eukaryotic nucleotide excision repair (NER), including nine major proteins identified by their mutation in humans and the development of UV-hypersensitivity as a result.
Is Rb protein involved in DNA repair?
Loss of retinoblastoma protein (RB1) function is a major driver in cancer development. We have recently reported that, in addition to its well-documented functions in cell cycle and fate control, RB1 and its paralogs have a novel role in regulating DNA repair by non-homologous end joining (NHEJ).
What does RAD50 stand for?
RAD50 (RAD50 Double Strand Break Repair Protein) is a Protein Coding gene. Diseases associated with RAD50 include Nijmegen Breakage Syndrome-Like Disorder and Inherited Cancer-Predisposing Syndrome.
What happens if RB is mutated?
In the familial form, a mutated allele is inherited along with a normal allele. In this case, should a cell sustain only one mutation in the other RB gene, all pRb in that cell would be ineffective at inhibiting cell cycle progression, allowing cells to divide uncontrollably and eventually become cancerous.
How does the p53 protein work?
Normal Function This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way. The p53 protein is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA.
