Can chemotherapy cause hypogammaglobulinemia?
Certain medications can also cause hypogammaglobulinemia, including: medicines that suppress the immune system, such as corticosteroids. chemotherapy drugs. antiseizure medications.
What medications can cause hypogammaglobulinemia?
Hypogammaglobulinemia may result from other anticonvulsants and anti-inflammatory medications, including valproic acid, phenytoin, gold, sulfasalazine, chloroquine, penicillamine, fenclofenac, hydantoin, zonisamide, lamotrigine, and cyclosporine A (1, 4, 5, 9).
What causes Hypoglobulinemia?
Hypogammaglobulinemia may result from lack of production, excessive loss of immunoglobulins, or both. Congenital disorders affecting B-cell development can result in complete or partial absence of one or more Ig isotypes.
What is the treatment for hypogammaglobulinemia?
The standard treatment for hypogammaglobulinemia is IgG replacement, which may be given intravenously or subcutaneously.
Is hypogammaglobulinemia a disability?
Hypogammaglobulinemia, a 21 letter mouthful that is as difficult to understand as to pronounce. On the surface, it is a rare immune disorder marked by a reduction in gamma globulins (serum proteins).
Is hypogammaglobulinemia common?
Hypogammaglobulinemia is by far the most common entity, comprising nearly half of all PID diagnoses (2, 4). In specialized centers, common variable immunodeficiency disorder (CVID) is the most common form of hypogammaglobulinemia seen (estimated prevalence in the population 1:10,000–50,000) (5, 6).
What causes Hypergammaglobulinemia?
Hypergammaglobulinemia is an uncommon condition that is usually the result of an infection, autoimmune disorder, or malignancy such as multiple myeloma. It’s characterized by elevated levels of immunoglobulins in your blood.
Is hypogammaglobulinemia a rare disease?
The World Health Organization (WHO) recognizes more than 400 primary immunodeficiencies ranging from relatively common to quite rare. CVID is one of the most prevalent of the symptomatic primary immunodeficiencies and manifests a wide variability of symptoms and range of severity.
Are there any side effects to chemotherapy for hypogammaglobulinemia?
Despite the hypogammaglobulinemia, most patients do not experience infectious complications prior to treatment with chemotherapy. Those who do, suffer recurrent sinopulmonary infections caused by bacteria that ravage patients with primary humoral immunodeficiency syndromes.
How does hypogammaglobulinemia affect the bone marrow?
It should be clear that cancer directly damages the bone marrow, which is the place where B cells are produced. It can also be caused by a genetic complication that disables all the antibodies produced. The secondary hypogammaglobulinemia is caused by a disorder that indirectly hinders the manufacture or action of the antibodies.
What to do if you have hypogammaglobulinemia?
Treatment options. Doctors treat bacterial infections with antibiotics. People who get severe or frequent bacterial infections may need to take antibiotics for several months at a time to prevent them. If your hypogammaglobulinemia is severe, you may get immune globulin replacement therapy to replace what your body isn’t making.
What kind of medications can cause hypogammaglobulinemia?
This also includes medications which can cause hypogammaglobulinemia such as corticosteroids, chemotherapy drugs, or antiseizure medication. Screening of immunoglobulin levels in relatives of CVID and IgA patients finds a familial inheritance rate of 10% to 20%.
