What drugs should not be taken with ranolazine?
Do not use ranolazine together with carbamazepine (Tegretol®), clarithromycin (Biaxin®), nefazodone (Serzone®), phenobarbital, phenytoin (Dilantin®), rifabutin (Mycobutin®), rifampin (Rifadin®, Rimactane®), rifapentine (Priftin®), medicine to treat fungus infections (eg, itraconazole, ketoconazole, Nizoral®, Sporanox®) …
Who should not take Ranexa?
You should not take Ranexa if you have cirrhosis of the liver. Serious drug interactions can occur when certain medicines are used together with ranolazine. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.
Is ranolazine a safe drug?
Ranolazine is a safe drug with minimal side effects. It is metabolized mainly in the liver and cleared by the kidney. Therefore, caution must be taken in patients with impaired hepatic or renal function.
Is ranolazine contraindicated in renal failure?
Renal impairment: Careful dose titration is recommended in patients with mild to moderate renal impairment (creatinine clearance 30–80 ml/min) (see sections 4.4, 4.8, and 5.2). Ranexa is contraindicated in patients with severe renal impairment (creatinine clearance < 30 ml/min) (see sections 4.3 and 5.2).
When is ranolazine used as a contraindication?
Ranolazine is contraindicated in patients with severe renal impairment (creatinine clearance < 30 ml/min), moderate or severe hepatic impairment, and in pregnant and breast-feeding women.
What’s the generic name for the drug ranolazine?
Ranolazine. Generic Name: ranolazine (ra NOE la zeen) Brand Name: Ranexa. Dosage Forms: oral tablet, extended release (1000 mg; 500 mg) Medically reviewed by Drugs.com on Sep 11, 2019. Written by Cerner Multum. Uses. Warnings. What to avoid.
How often should I increase my dose of ranolazine?
Dose may be further increased to 750mg twice daily if tolerated, where symptoms are on-going. If patients experience treatment related side effects, down titration to 500mg bd or 375mg bd may be required. 4. DRUG INTERACTIONS Drug interactions where concomitant use of ranolazine is contraindicated:
Is it safe to take ranolazine while breastfeeding?
5. CONTRAINDICATIONS AND CAUTIONS Ranolazine is contraindicated in patients with severe renal impairment (creatinine clearance < 30 ml/min), moderate or severe hepatic impairment, and in pregnant and breast-feeding women. There are a number of clinically significant drug interactions listed with ranolazine – see details above.
