What is gelsolin amyloidosis?
Abstract. Hereditary gelsolin amyloidosis (HGA) is an autosomally dominantly inherited form of systemic amyloidosis, characterized mainly by cranial and sensory peripheral neuropathy, corneal lattice dystrophy, and cutis laxa.
What type of actin-binding protein can gelsolin be classified as?
Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency….Gelsolin (cellular)
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What is the role of cofilin?
Cofilin is one of the most affluent and common actin-binding proteins and plays a role in cell motility, migration, shape, and metabolism. They also play an important role in severing actin filament, nucleating, depolymerizing, and bundling activities.
What kind of ribbon is used for cancer awareness?
If you wish to familiarize yourself, here’s a list of cancer ribbons that are used to raise awareness for common cancers, as well as the awareness months some have associated with them. A light purple or lavender ribbon is generally used to represent all cancers as a whole.
When to wear a ribbon for carcinoid syndrome?
Carcinoid Syndrome – Black and white zebra-striped (November) If you or a loved one has cancer, or you simply want to raise awareness for cancer (or all cancers), wearing a colored ribbon can be your first step. Your support for cancer education and compassion will not go unnoticed. Was this page helpful? Thanks for your feedback!
What does gelsolin do in the human body?
Plasma gelsolin’s ability to sever actin filaments helps the body recover from disease and injury that leaks cellular actin into the blood. Additionally it plays important roles in host innate immunity, activating macrophages and localizing of inflammation . Gelsolin is an 82-kD protein with six homologous subdomains, referred to as S1-S6.
What kind of lipid does gelsolin bind?
Among the lipid -binding actin regulatory proteins, gelsolin (like cofilin) preferentially binds polyphosphoinositide (PPI). The binding sequences in gelsolin closely resemble the motifs in the other PPI-binding proteins. Gelsolin’s activity is stimulated by calcium ions (Ca 2+ ).
