Can yolk sac tumor arise from mature cystic teratoma?
Final Diagnosis — Yolk sac tumor. FINAL DIAGNOSIS: Yolk sac tumor arising in association with mature cystic teratoma (dermoid cyst). DISCUSSION: Yolk sac tumor (also known as endodermal sinus tumor) of the ovary is a malignant germ cell neoplasm.
What is metastatic yolk sac tumor?
A yolk sac tumor is a rare, malignant tumor of cells that line the yolk sac of the embryo. These cells normally become ovaries or testes; however, the cause of a yolk sac tumor is unknown. It is most often found in children before the ages of 1 to 2, but can occur throughout life.
What kind of tumor is an ovarian yolk sac?
Background: Whereas among pediatric oncologists, ovarian yolk sac tumor (O-YST) is considered a chemosensitive tumor, it is often cited as an adverse prognostic factor in adult women with ovarian germ cell tumors.
How old do you have to be to have a yolk sac tumor?
Age was modeled as a continuous and a categorical variable (children, 0-10 years; adolescents, 11-17 years; and adults, ≥18 years). In addition, analyses to establish the optimal cut point for age were conducted.
What kind of atypia is found in yolk sac tumor?
Cytological atypia is variable across patterns; it is most significant in solid, sarcomatoid and glandular patterns Characteristic (but not pathognomonic) hyaline globules (within and outside cytoplasm), refractile and eosinophilic, which are alpha-1-antitrypsin+ and PAS diastase+
Which is more aggressive stage 1 or Stage 3 yolk sac?
More aggressive (compared to prepubertal): around 40% stage I disease; metastatic rate of 33%; stage III patients with yolk sac elements display poorer prognosis; increased prevalence in late recurrences (chemoresistance) Less aggressive (compared to postpubertal): 80% stage I disease; of these 6% relapse on surveillance only
