Does neuraminidase bind to sialic acid?
This promotes the release of progeny viruses and the spread of the virus from the host cell to uninfected surrounding cells. Neuraminidase also cleaves sialic acid residues from viral proteins, preventing aggregation of viruses.
How does neuraminidase cleave sialic acid?
Neuraminidase cleaves terminal sialic acid residues from cellular and viral membrane glycoproteins, thus destroying the cellular receptors recognized by the viral hemagglutinin.
What is the function of neuraminidase protein?
Neuraminidase cleaves the sialic acid molecule, thereby freeing the virus to infect other cells in the host organism. Antibodies against neuraminidase that are generated by the host’s immune system following infection bind to a portion of the neuraminidase antigen known as an epitope.
What is neuraminidase made of?
The influenza virus particle is made up of the viral RNA genome wrapped in a lipid membrane (illustrated).
Where does neuraminidase cleave the sialic acid chain?
Neuraminidase is a glycohydrolase which cleaves the α-ketosidically linked sialic acid (neuraminic acid), 3, off the ends of the glycosidic side chains of hemagglutinin and other glycoproteins and glycolipids. From: Comprehensive Medicinal Chemistry II, 2007.
How are neuraminidases related to microbial infections?
Sialidases may act as pathogenic factors in microbial infections. There are two major classes of Neuraminidase that cleave exo or endo poly-sialic acids: Neuraminidases, also called sialidases, catalyze the hydrolysis of terminal sialic acid residues from the newly formed virions and from the host cell receptors.
Is there a way to block the function of neuraminidase?
Since the cleavage of the sialic groups is an integral part of influenza replication, blocking the function of neuraminidase with neuraminidase inhibitors is an effective way to treat influenza. A single hemagglutinin-neuraminidase protein can combine neuraminidase and hemagglutinin functions, such as in mumps virus and human parainfluenza virus .
What kind of cation is produced by neuraminidase?
C. diphtheriae produce neuraminidase, which cleaves N -acetylneuraminic acid (NAN) from cell surfaces to produce pyruvate (a growth stimulant). Neuraminidases have different requirements for divalent cations.
