What are the signs of liver failure in dogs?
The early signs of liver disease in dogs are nonspecific. They include loss of appetite, weight loss, and chronic intermittent vomiting and diarrhoea. Vomiting is more common than diarrhoea. Drinking and urinating more often than normal may be the first signs, and the principal reason for seeking medical attention.
What toxins cause liver failure in dogs?
Xylitol and paracetamol are commonly encountered substances which can cause liver toxicity in dogs. Some blue-green algae (cyanobacteria) and mushrooms produce compounds that damage the liver. Acute ingestion of some plants, particularly cycads, can cause liver failure in dogs.
What drugs cause liver damage in dogs?
Many drugs have been suspected of causing hepatic injury in dogs and cats. Most adverse hepatic drug reactions are associated with acute hepatic injury. However, some drugs, most notably Phenobarbital, lomustine, oxibendazole/DEC (and possibly carprofen and amiodarone) may be a cause of chronic hepatic injury.
How are polycyclic aromatic hydrocarbons ( PAHs ) metabolized in the liver?
Agency for Toxic Substances and Disease Registry (ATSDR) Case Studies in Environmental Medicine Toxicity of Polycyclic Aromatic Hydrocarbons (PAHs) Metabolism and Excretion. PAHs are predominantly metabolized via CYP enzymes (enzymes in the P-450 mixed-function oxidase system) in the liver [Kapitulnik et al.
How to learn about the toxicity of polycyclic aromatic hydrocarbons?
Instructions To make the most effective use of this course. • Take the Initial Check to assess your current knowledge about the toxicity of polycyclic aromatic hydrocarbons. • Read the title, learning objectives, text, and key points in each section. • Complete the progress check exercises at the end of each section and check your answers.
Are there any case studies of the toxicity of PAHs?
Agency for Toxic Substances and Disease Registry (ATSDR) Case Studies in Environmental Medicine Toxicity of Polycyclic Aromatic Hydrocarbons (PAHs) Acknowledgements We gratefully acknowledge the work that the medical writers, editors, and reviewers have provided to produce this educational resource.
How are PAH metabolites harmful to the environment?
Key Concepts • Because of combustion of fossil fuels and organic waste, PAHs are ubiquitous in the environment • Studies show that certain PAH metabolites interact with DNA and are genotoxic, causing malignancies and heritable genetic damage in humans.
