What is p63 staining?
Typically a nuclear stain. Cytoplasmic staining of Z bands of benign and malignant skeletal muscle tumors (Mod Pathol 2011;24:1320)
Is p63 negative good or bad?
There was a significant statistical difference between squamous cell carcinoma and adenocarcinoma in p63 staining (p=0.002). P63 was strongly positive in all of 12 squamous carcinoma in situ cases, but in 83.3% of atypical adenomatous hyperplasia, p63 was negative.
What does negative for p63 mean?
p63 is negative in malignant tumors of the prostate. Striated muscle staining may be observed with p63. Interpretation. This test does not include pathologist interpretation, only technical performance of the stain.
What is E cadherin positive mean?
E-cadherin is a test that the pathologist might use to help determine if the tumor is ductal or lobular. (The cells in invasive lobular carcinomas are often negative for E-cadherin.) If your report does not mention E-cadherin, it means that this test was not needed to tell what type of cancer you have.
Is there striated muscle staining with p63 antibody?
Striated muscle staining may be observed with p63. Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.
What kind of breast cancer has p63 expression?
In this study, we determined p63 expression in a large number of breast carcinomas, including metaplastic carcinomas, and in Phyllodes tumors and sarcomas.
Can a P63 antibody be used to detect prostate cancer?
p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. p63 is detected in prostatic basal cells in normal prostate; however, it is negative in malignant tumors of the prostate gland. Thus p63 antibody may be a valuable tool in the differential diagnosis…
Is there a specific marker for metaplastic carcinoma?
All Phyllodes tumors and sarcomas were consistently negative for p63 expression. The sensitivity and specificity of p63 as a diagnostic marker for metaplastic carcinoma was 86.7% and 99.4%, respectively.
