What is definitive hematopoiesis?
Definitive hematopoiesis generates hematopoietic stem/progenitor cells (HSPCs) that give rise to all mature blood and immune cells, but remains poorly defined in human. Here, we resolve human hematopoietic populations at the earliest hematopoiesis stage by single-cell RNA-seq.
What is abnormal hematopoiesis?
Definition: abnormal development of blood cells in the fetal and adult organism; in the fetus cells develop in the aorta, genital ridge and mesonephros region and later in the liver; in adults cells normally develop in the bone marrow and lymphatic tissues.
What is Extraembryonic hematopoiesis?
Extraembryonic hematopoiesis: The yolk sac The first hematopoietic emergence, a process named primitive hematopoiesis, starts during the third week of human development, before the establishment of the blood flow, in an extraembryonic tissue—the yolk sac (YS)—which is composed of visceral endoderm and mesoderm [3].
What is the process and regulation of hematopoiesis?
Normal hematopoiesis is a well-regulated process in which the generation of mature blood elements occurs from a primitive pluripotent stem cell in an ordered sequence of maturation and proliferation.
Where is the village of Berkel Enschot located?
Berkel-Enschot is located between Tilburg and Oisterwijk. Surrounding towns and hamlets are Brem, Heikant, Heuveltje, ‘t Hoekske, Hoog-Heukelom, Hoogeind, de Kraan, Laag-Heukelom, Loonse Hoek, Oisterwijkse Hoeve and Udenhout. The village was formed when two agricultural villages, Berkel and Enschot, eventually merged.
Who are the scientists who study hematopoiesis?
Zakary L. Whichard, Casim A. Sarkar, Marek Kimmel, Seth J. Corey; Hematopoiesis and its disorders: a systems biology approach. Blood 2010; 115 (12): 2339–2347. doi: https://doi.org/10.1182/blood-2009-08-215798 Scientists have traditionally studied complex biologic systems by reducing them to simple building blocks.
How does systems biology improve our understanding of hematopoiesis?
Altogether, systems biology will improve our understanding of normal and abnormal hematopoiesis, better define stem cells and their daughter cells, and potentially lead to more effective therapies.
Which is the best animal model for hematopoiesis?
Engraftment of human HSC in utero in fetal sheep is also used as an experimental model of human hematopoiesis. The early stages of mammalian hematopoiesis, which begins in the blood islands of the yolk sac, may be divided into two developmental processes (Fig.2 ).
