What is cisplatin-induced ototoxicity?
Cisplatin ototoxicity is produced by several distinct mechanisms [16] as depicted in Figure 1. One such mechanism, the antioxidant model, involves the formation of reactive oxygen species (ROS) within the cochlea and consequent reduction in antioxidant enzymes following exposure to cisplatin chemotherapy [16–20].
What type of hearing loss does cisplatin cause?
But cisplatin and other similar platinum-containing drugs can damage the cochlea, leaving 40%–80% of adults, and at least 50% of children, with significant permanent hearing loss, a condition that can greatly affect quality of life.
Is oxaliplatin ototoxic?
Oxaliplatin is used to treat advanced colorectal cancer. Platinum-containing chemotherapeutic agents are known to be ototoxic. However, ototoxicity is rare with newer generation platinum-derived agents, such as oxaliplatin.
Is gentamicin ototoxic?
Conclusions: Gentamicin ototoxicity is vestibular, not cochlear, producing permanent loss of balance, but not of hearing. Gentamicin can be vestibulotoxic in any dose, in any regimen, at any serum level.
Is there a link between cisplatin and ototoxicity?
Unfortunately some can also damage or kill cells elsewhere in the body, including the ears. Cisplatin is well known to cause massive and permanent hearing loss. Carboplatin is also known to be ototoxic.” Managing any drug-induced ear problems by learning the symptoms could avoid any longer-term chronic conditions.
Are there any chemotherapy drugs that cause ototoxicity?
Cisplatin is well known to cause massive and permanent hearing loss. Carboplatin is also known to be ototoxic.” Managing any drug-induced ear problems by learning the symptoms could avoid any longer-term chronic conditions. How Do Chemotherapy Drugs Cause Ototoxicity? Some chemotherapy drugs like Cisplatin can cause ototoxicity if used long term.
How often do cisplatin patients suffer hearing loss?
Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss. As cisplatin is widely used, this rate of ototoxicity translates to hundreds of thousands of patients affected each year in the United States alone. chemo, cancer, hearing loss
What are the side effects of cisplatin in cancer patients?
As the population of cancer survivors continues to grow, so does the importance of addressing their medical needs. For patients treated with the chemotherapeutic drug cisplatin, one common consequence of treatment is permanent hearing loss.
