Is LogP the same as pH?
Log D is a distribution coefficient widely used to measure the lipophilicity of ionizable compounds, where the partition is a function of the pH. For non-ionizable compounds Log P = Log D throughout pH range, whereas for ionizable compounds Log D takes into account the partition of both ionized and non-ionized forms.
What is LogP in drug design?
LogP is a component of Lipinski’s Rule of 5 a rule of thumb to predict solubility and permeability that has become a surrogate for drug-likeness. The most commonly used measure of lipophilicity is LogP, this is the partition coefficient of a molecule between an aqueous and lipophilic phases, usually octanol and water.
What is LogP water?
Partition coefficient of a solvent1/ water system might be defined as the ratio of a chemical’s concentration in the solvent1 phase to its concentration in the aqueous phase. Log of this partition coefficient, log P is used to measure the hydrophobicity. …
How do I calculate the p value in statistics?
Introduction to calculating a p-value. The p-value is calculated using the test statistic calculated from the samples, the assumed distribution, and the type of test being done. One way of describing the type of test is by the number of tails. For a lower-tailed test, p-value = P(TS < ts | H 0 is true) = cdf(ts)
What is the significance level of p value?
In most sciences, results yielding a p-value of .05 are considered on the borderline of statistical significance. If the p-value is under .01, results are considered statistically significant and if it’s below .005 they are considered highly statistically significant.
What is p value interpretation?
the p-value is usually incorrectly interpreted as it is usually interpreted as the probability of making a mistake by rejecting a true null hypothesis (a Type-I error). the p-value cannot be error rate because: the p-value is calculated based on the assumption that the null hypothesis is true and that the difference in the sample by random chances.
What is logP and log d?
logD is a log of partition of a chemical compound between the lipid and aqueous phases . The most popular lipid phase is octanol. LogP is equivalent to logD for non-ionisable compounds and represents the partition of the neutral form for ionizable compounds (and, hence, is a virtual, unmeasurable, property).
