What are the side effects of taking tibolone?
Side effects of tibolone can include tummy (abdominal) pain, pelvic pain, breast tenderness, itching and vaginal discharge. Risks of tibolone are similar to the risks of HRT, and include an increased risk of breast cancer and strokes.
What is the best time of day to take tibolone?
Take one 2.5 mg tablet every day. You may take tibolone at whatever time of day you find easiest to remember, but try to take your doses at the same time of day, each day. You can take the tablets before or after meals. You may find it helps to swallow the tablet with a drink of water.
Does tibolone make you gain weight?
Overall tibolone was well tolerated and climacteric symptoms were relieved within 3-5 weeks. The major side effect was weight gain and/or a tendency to bloating and oedema which occurred in 11.28% of our women.
How long does it take for tibolone to start working?
It usually takes a few weeks before you will feel the initial benefits of HRT and up to three months to feel the full effects. It may also take your body time to get used to HRT. When treatment begins you may experience side effects such as breast tenderness, nausea and leg cramps.
Does tibolone help anxiety?
In our study, we found that tibolone was superior to placebo in anxiety and Kupperman index scores. In menopausal women, the psychological benefits of HT may occur because of the relief of vasomotor symptoms and a reduction in vaginal dryness, and this is known as the ‘domino effect’ (2).
Is tibolone a steroid?
Tibolone (TIB) is a synthetic steroid with estrogenic, androgenic, and progestogenic actions that can be used as HRT.
When should I stop taking tibolone?
Stopping HRT There’s no limit on how long you can take HRT, but talk to a GP about how long they recommend you take the treatment. Most women stop taking it once their menopausal symptoms pass, which is usually after a few years.
Can tibolone cause hair loss?
Side effects with Tibolone were rare, and DHEA mainly caused androgenic side effects like acne and hair loss (Table 4).
Does tibolone affect the liver?
The severity of liver injury due to tibolone has varied from mild, transient serum enzyme elevations to moderately severe acute hepatitis. No instances of acute liver failure, death, or chronic hepatitis have been linked to tibolone use.
Why is tibolone banned in US?
US regulators have rejected Organon’s enzyme replacement therapy Livial (tibolone) for the treatment of menopausal symptoms in women, prompting the company – the human healthcare unit of Dutch concern Akzo Nobel – to withdraw its application in the country.
Does tibolone raise blood pressure?
This study suggests that tibolone has no deleterious effect on blood pressure in women with hypertension but has contrasting effects on biochemical risk factors. Large-scale studies are required to determine the overall effect of tibolone on cardiovascular morbidity and mortality.
Are there any side effects to taking tibolone tablets?
If you (or a close family member) have had breast cancer. If you have had a cancer that you have been told is hormone-dependent. If you have any unexplained vaginal bleeding. If you have liver disease, or if you have any problems with the way your kidneys work. If you know you have high levels of fat (triglycerides or cholesterol) in your blood.
When to take tibolone 2.5 mg tablets after menopause?
• Treatment of oestrogen deficiency symptoms in postmenopausal women, more than one year after menopause. • Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis. (See also Section 5.1)
How is tibolone used in hormone replacement therapy?
Livial tablets contain the active ingredient tibolone, which is a synthetic steroid medicine used for hormone replacement therapy (HRT). It mimics the activity of the female sex hormones in the body. Livial contains tibolone, a substance that has favourable effects on different tissues in the body, such as brain, vagina and bone.
How much lactose is in a tibolone tablet?
Excipient (s) with known effect: each tablet contains 43.2 mg of lactose monohydrate. For the full list of excipients, see section 6.1. 3. Pharmaceutical form Tablet. White to off-white round uncoated tablets of 6 mm diameter with bevelled edge without any marking. 4. Clinical particulars
