What is the combinatorial control of gene expression?
Combinatorial gene regulation provides a mechanism by which relatively small numbers of transcription factors can control the expression of a much larger number of genes with finely tuned temporal and spatial patterns.
What is combinatorial control of transcription in gene regulation?
Most importantly is the idea of combinatorial control, which is that any given gene is likely controlled by a specific combination of factors to control transcription. In a hypothetical example, the factors A and B might regulate a distinct set of genes from the combination of factors A and C.
What factors control gene expression?
Adding further complexity is that the control of gene expression can occur at multiple steps: accessibility of a gene to activating transcription factors, transcription initiation, transcript elongation, splicing of the pre-mRNA, as well as post-transcriptional regulation.
What are the four levels of control of gene expression in eukaryotes?
Eukaryotic Repressors Gene expression in eukaryotic cells is regulated by repressors as well as by transcriptional activators. Like their prokaryotic counterparts, eukaryotic repressors bind to specific DNA sequences and inhibit transcription.
Which is the combinatorial control of gene expression?
Soumya Bhattacharjee, Kaushik Renganaath, Rajesh Mehrotra, Sandhya Mehrotra, ” Combinatorial Control of Gene Expression “, BioMed Research International, vol. 2013, Article ID 407263, 11 pages, 2013. https://doi.org/10.1155/2013/407263 The complexity and diversity of eukaryotic organisms are a feat of nature’s engineering.
How is the specificity of gene signals affected by Combinatorial regulation?
On the other hand, the specificity of signals cannot be compromised. Since each gene is under the control of more than one type and number of cis-regulatory elements, a combinatorial regulation enables the organism to have innumerable expression patterns even with a limited number of transcription factors.
Which is an example of a combinatorial control?
It is an amalgamation, an interplay between several processes, pathways, and factors—a combinatorial control. A short description of some of the most important elements that operate this entire conglomerate is given in this paper. 1. Introduction
How is transcriptional control of a gene achieved?
Transcriptional control can be achieved at any of the various stages—initiation, elongation, and termination. Initiation is marked by the assembly of the preinitiation complex at the promoter of the corresponding gene.
