What happens when clopidogrel is given with a PPI?
Proton pump inhibitors are inhibitors of CYP2C19 with varying degrees of potency. Therefore, PPIs may inhibit activation of clopidogrel to its active metabolite via CYP2C19 leading to decreased serum concentrations of the active metabolite and potentially reducing the antiplatelet effect of clopidogrel.
Is there an interaction between clopidogrel and omeprazole?
In conclusion, even though pharmacodynamic studies suggest that omeprazole can attenuate the antiplatelet effect of clopidogrel, this interaction does not appear to translate into increased cardiovascular risk in patients treated with this combination. Other PPIs also do not appear to interact with clopidogrel.
Why PPI decrease the effect of clopidogrel?
Clopidogrel is a prodrug which requires cytochrome P450 2C19 (CYP 2C19) enzyme for its conversion to an active thiol metabolite. Proton pump inhibitors (PPIs) inhibits enzyme CYP 2C19 interfering with the conversion of clopidogrel into its active metabolite.
Do proton pump inhibitors reduce the clinical efficacy of clopidogrel?
All PPIs are also metabolised via the cytochrome P450 system, particularly CYP2C19 and CYP3A4. All PPIs inhibit these isoenzymes to different degrees and therefore could affect the clinical efficacy of clopidogrel.
What drug brand names are proton pump inhibitors?
List of Proton Pump Inhibitors Omeprazole. The first proton pump inhibitor, omeprazole, was introduced in 1989. Lansoprazole. Lansoprazole comes in 15 and 30 mg doses. Rabeprazole. Rabeprazole is available as the brand name drug Aciphex or in generic versions. Pantoprazole. Pantoprazole is available by the brand name Protonix or in a generic drug. Esomeprazole. Dexlansoprazole.
Which drugs reaact with proton pump inhibitors?
Proton pump inhibitor drug interactions can happen with medicines ranging from aspirin to cancer drugs . People should be aware of how proton pump inhibitors interact with other drugs they take. PPIs alter the pH of the stomach. The pH is a measure of stomach acidity. An altered pH can change the way certain drugs work within the body.
What are the most common clopidogrel interactions?
The most common clopidogrel interactions are seen in patients who use any type of proton pump inhibitor medications together with clopidogrel. The intake of proton pump inhibitors within 12 hours of taking clopidogrel greatly reduces platelet inhibition. This increases the risk of clot formation.
What drugs interact with Plavix?
Plavix may interact with other blood thinners, aspirin, or nonsteroidal anti-inflammatory drugs ( NSAIDs ). Plavix may also interact with armodafinil, modafinil , fluoxetine , fluvoxamine, gemfibrozil , isoniazid , cancer medications, stomach acid reducers, antifungals, HIV medications, or seizure medications.
