What is the gene code for AMPK?
Hear this out loudPause5′-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene. The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5′-prime-AMP-activated protein kinase (AMPK).
Is AMPK a gene?
Hear this out loudPauseIn mammals, there are two genes encoding the AMPK α catalytic subunit (α1 and α2), two β genes (β1 and β2) and three γ subunit genes (γ1, γ2 and γ3)22.
What is PRKAG2 gene?
Hear this out loudPauseThe PRKAG2 gene provides instructions for making one part (the gamma-2 subunit) of a larger enzyme called AMP-activated protein kinase (AMPK). This enzyme helps sense and respond to energy demands within cells.
What phosphorylates AMPK?
Hear this out loudPauseAMP-activated protein kinase (AMPK) plays a key role as a master regulator of cellular energy homeostasis. AMPK can also be directly phosphorylated on Thr172 by CAMKK2 in response to changes in intracellular calcium as occurs following stimulation by metabolic hormones including adiponectin and leptin.
What is the function of the PRKAA1 gene?
Tocris Summary for PRKAA1 Gene. AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival during times of cellular metabolic stress.
What kind of protein is resultprkaa1 AMP activated?
5562 – Gene ResultPRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 [ (human)] The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5′-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells.
How is PRKAA1 related to fatty liver disease?
PRKAA1 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) is a Protein Coding gene. Diseases associated with PRKAA1 include Fatty Liver Disease and Wolff-Parkinson-White Syndrome . Among its related pathways are Cellular Senescence (REACTOME) and Tight junction .
How is ampkalpha1 and PRKAA1 related to progression free survival?
Protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1) rs13361707 and PRKAA1 rs10074991 significantly associated with progression-free survival (PFS) [Meta-analysis]. Phosphorylation of AMPKalpha1 by PIM2 led to decreasing AMPKalpha1 kinase activity, which in turn promoted aerobic glycolysis and tumor growth.
