What are allergic reactions to Taxol?
Mouth sores. Hypersensitivity reaction. Fever, facial flushing, chills, shortness of breath, or hives after Paclitaxel is given (see allergic reaction). The majority of these reactions occur within the first 10 minutes of an infusion.
What do people react to in Taxol?
Respiratory distress (dyspnea and/or bronchospasm), hypotension, and angioedema were the major manifestations, but flushing, urticaria, chest, abdomen, and extremity pains were described also. Reactions occurred on first exposure in the majority of cases raising etiologic questions.
How long does infusion reaction last?
The most common adverse effects include fever, chills, rash, and nausea occurring during the first infusion. Infusion reactions typically occur within 30 to 120 minutes and resolve with discontinuation of the infusion and supportive care.
Can paclitaxel cause infusion reactions?
Many patients receiving paclitaxel experience mild to severe infusion-related hypersensitivity reactions, such as uticaria, facial flushing, shortness of breath, angioedema, and anaphylaxis. Most reactions occur during the first or second infusion, 78% within the first 10 to 15 minutes of drug initiation.
What are the side effects of first infusion of paclitaxel?
Many patients receiving paclitaxel experience mild to severe infusion-related hypersensitivity reactions, such as uticaria, facial flushing, shortness of breath, angioedema, and anaphylaxis. Most reactions occur during the first or second infusion, 78% within the first 10 to 15 minutes of drug initiation.
How to treat hypersensitivity to docetaxel and paclitaxel?
Routine premedication with glucocorticoids can diminish the incidence of hypersensitivity during paclitaxel or docetaxel therapy from 30% to 3%,. With premedication, the incidence of hypersensitivity reactions to paclitaxel is between 1% and 3% regardless of infusion time (1, 3, or 24 hours).
How are taxanes used to treat hypersensitivity reactions?
Abstract Taxanes (a class of chemotherapeutic agents) are an important cause of hypersensitivity reactions (HSRs) in cancer patients. During the last decade, the development of rapid drug desensitization has been key to allow patients with HSRs to taxanes to be safely re- treated although the mechanisms of these HSRs are not fully understood.
Are there any drugs that can cause an infusion reaction?
The cytotoxic agents that are most commonly associated with infusion reactions are the taxanes, platinum drugs, pegylated liposomal doxorubicin, asparaginase, procarbazine, etoposide, bleomycin, cytarabine, and ixabepilone.
