What drugs are metabolized by CYP2D6?
CYP2D6 metabolizes around 25% of currently prescribed drugs, including various antidepressants, neuroleptics, beta-blockers, opioids, antiemetics, and antiarrhythmics.
Is risperidone metabolized by CYP2D6?
Risperidone is an active compound that is mainly metabolized in the liver by cytochrome P450 enzymes such as CYP2D6. An active metabolite in the main hydroxylation pathway is 9-hydroxyrisperidone. Another minor metabolic pathway involves N-dealkylation (Fang et al., 1999).
What is the CYP2D6 gene?
CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6) is a Protein Coding gene. Diseases associated with CYP2D6 include Drug Metabolism, Poor, Cyp2d6-Related and Neuroleptic Malignant Syndrome. Among its related pathways are Cytochrome P450 – arranged by substrate type and Codeine and Morphine Metabolism.
What is the CYP2D6 enzyme?
Cytochrome P450 2D6 (CYP2D6) CYP2D6 is an enzyme that is responsible for breaking down (metabolizing) many of the drugs that are commonly used today. Some medications, such as codeine, require activation by CYP2D6 in order for the medication to be effective.
What is the sequence of the CYP2D6 gene?
Kimura S, Umeno M, Skoda R C et al. The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am J Hum Genet 1989;45:889-904.
What happens if you take CYP2D6 at the same time?
CYP2D6. If such a drug is taken at the same time as a second drug that is a CYP2D6 substrate, the first drug may affect the elimination rate of the second through what is known as a drug-drug interaction.
Is there a diagnostic SNP for CYP2D6 * 13?
There is no diagnostic SNP for CYP2D6*13, and thus assigning it is best done by sequencing the entire gene region. See Sim et al., 2012 for more information.
What are the alleles of CYP2D6 in pharmvar?
All CYP2D6*13 alleles share a CYP2D7/2D6 hybrid gene structure, with CYP2D7 sequence in exon 1 leading to an insertion (137_138insT) and frameshift of the open reading frame, thereby obliterating enzyme activity.
