What is a Centroblast?
Centroblasts are usually large (nuclear diameter greater than that of a histiocyte or nonactivated endothelial cell) with irregular round nuclei, dispersed chromatin, multiple nuclei that often abut the nuclear membrane, and modest amounts of cytoplasm.
What is a Centrocyte?
A centrocyte generally refers to a B cell with a cleaved nucleus, as may appear in e.g. follicular lymphoma. Centrocytes are B cells that are found in the light zones of germinal centers.
Where are Centroblasts found?
germinal center
A centroblast generally refers to an activated B cell that is enlarged (12–18 micrometer) and is rapidly proliferating in the germinal center of a lymphoid follicle. They are specifically located in the dark zone of the germinal center.
What are Immunoblasts?
Immunoblasts are the most immature members of the protective cells involved in an immune response. Activated B cells may differentiate into memory cells or plasma cells, while activated T cells may differentiate into memory cells or effector cells that aid in the immune response.
Where are centrocytes found in a B cell?
A centrocyte generally refers to a B cell with a cleaved nucleus, as may appear in e.g. follicular lymphoma. Centrocytes are B cells that are found in the light zones of germinal centers.
Where are centroblasts located in the human body?
They are specifically located in the dark zone of the germinal center. Centroblasts form from naive B cells being exposed to follicular dendritic cell cytokines, such as IL-6, IL-15, 8D6, and BAFF. Stimulation from helper T cells is also required for centroblast development.
What does centrocyte stand for in medical terms?
Centrocyte can also refer to a cell with a protoplasm that contains single and double granules of varying size stainable with hematoxylin, as seen in lesions of lichen planus, or a nondividing, activated B cell that expresses membrane immunoglobulin. [1] Stedman’s Medical Dictionary. 2006.
Where are centroblasts located in the lymphoid follicle?
A centroblast generally refers to an activated B cell that is enlarged (12–18 micrometer) and is rapidly proliferating in the germinal center of a lymphoid follicle. They are specifically located in the dark zone of the germinal center.
