Does HCTZ increase calcium levels?
Diuretics: Thiazide diuretics like hydrochlorothiazide (Microzide) and chlorthalidone are used to treat high blood pressure, but high calcium levels are a well-known side effect. These medications can raise calcium levels by preventing calcium from being released in the urine, which can also lead to kidney stones.
Why does HCTZ cause hypercalcemia?
Hypercalcemia associated with thiazide use is a well-known clinical entity. Thiazides exert their antihypertensive effect through an increase in sodium excretion by blocking the thiazide-sensitive NaCl transporter in the distal convoluted tubule, which is closely linked to calcium transport (5).
Can diuretics cause hypercalcemia?
Thiazide diuretics can increase renal tubular reabsorption of calcium, resulting in hypercalcemia.
Does hydrochlorothiazide remove calcium?
Hydrochlorothiazide (Microzide) HCTZ is the most frequently used thiazide in the reduction of urinary calcium levels.
How does HCTZ affect calcium?
Hydrochlorothiazide and Supplemental Calcium. In addition to their effects on your sodium retention, hydrochlorothiazide and all other thiazide diuretics can increase the calcium levels in your bloodstream by interfering with the normal excretion of calcium in your urine. If you take these medications in combination with high doses…
What medications reduce calcium levels?
Calcium and Anti-Seizure Medications. Anti-seizure medications, such as phenytoin, carbamazepine, phenobarbital, and primidone, may lower your calcium levels. They need to be taken at least two hours apart from calcium supplements.
What causes elevated calcium?
Examples of granulomatous diseases that cause elevated calcium levels include tuberculosis, candidiasis, histiocytosis, sarcoidosis and Crohn’s disease. High calcium in the blood occurs because these diseases cause elevated calcitriol levels.
What causes extremely high ionized calcium?
If you have a high level of ionized calcium in your blood, it can indicate: milk-alkali syndrome , which is high levels of calcium in the body due to consuming too much milk, antacids, or calcium carbonate over time multiple myeloma, which is cancer of the plasma cells (a type of white blood cell that produces antibodies)
