What are solid supported reagents?
A solid-supported reagent is simply a reagent that has been covalently or ionically attached to a polymer resin. This allows a solution of a building block(s) to be added to a reaction vessel containing the solid-supported reagent and then drained away easily after the reaction is completed (Figure 8).
What is solid phase organic synthesis?
Solid-phase organic synthesis is an essential method for the rapid synthesis of complex biological structures and libraries of small organic molecules. However, it is often associated with the use of large quantities of problematic solvents for the removal of excess reagents and reaction by-products.
What are reagents in organic chemistry?
In organic chemistry, the term “reagent” denotes a chemical ingredient (a compound or mixture, typically of inorganic or small organic molecules) introduced to cause the desired transformation of an organic substance. Examples include Fehling’s reagent, Millon’s reagent, and Tollens’ reagent.
What is the synthesis of organic compounds?
Organic synthesis is the artificial construction of more complex organic molecules from simpler ones using chemical reactions. The reasons for doing organic synthesis are varied.
How are solid supported reagents used in organic synthesis?
Abstract:The current interest in solid-phase organic synthesis has led to a renewed interest in a complementary technique in which solid supported reagents are used in solution phase chemistry.
How is solid phase synthesis used in chemistry?
In chemistry, solid-phase synthesis is a method in which molecules are covalently bound on a solid support material and synthesised step-by-step in a single reaction vessel utilising selective protecting group chemistry. Benefits compared with normal synthesis in a liquid state include:
Which is the best method for multi step organic synthesis?
Various methods have been developed in combinatorial chemistry so far which include solid-phase synthesis, solution-phase synthesis, fluorous-phase synthesis and other combinations of the above.
Which is an example of a supported reagent system?
The concept of immobilising reagents on a support material is not new; catalytic hydrogenation and numerous other heterogeneous reactions that occur at the interface of a solid can be classified as examples of supported-reagent systems. It is conceivable that with the appropriate choice of support a diverse array of reagents could be tethered.
